Introduction to Biotechnology - Environmental Biotechnology: Theory and Application - page 2

natural selection as fundamental. The irony is that Darwin himself rejected muta-
tion as too deleterious to be of value, seeing such organisms, in the language
of the times, as 'sports' - oddities of no species benefit. Indeed, there is consid-
erable evidence to suggest that he seems to have espoused a more Lamarckist
view of biological progression, in which physical changes in an organism's life-
time were thought to shape future generations. Darwin died in 1882. Ninety-nine
years after his death, the first patent for a genetically modified organism was
granted to Ananda Chakrabarty of the US General Electric, relating to a strain of
Pseudomonas aeruginosa engineered to express the genes for certain enzymes in
order to metabolise crude oil. Twenty years later still, in the year that saw the first
working draft of the human genome sequence published and the announcement of
the full genetic blueprint of the fruit fly, Drosophila melanogaster , that archetype
of eukaryotic genetics research, biotechnology has become a major growth indus-
try with increasing numbers of companies listed on the world's stock exchanges.
Thus, at the other end of the biotech timeline, a century and a half on from Ori-
gin of Species , the principles it first set out remain of direct relevance for what
has been termed the 'chemical evolution' of biologically active substances and
are commonly used in laboratories for in vitro production of desired qualities in
biomolecules.
The Role of Environmental Biotechnology
While pharmaceutical biotechnology represents the glamorous end of the market,
environmental applications are decidedly more in the Cinderella mould. The
reasons for this are fairly obvious. The prospect of a cure for the many diseases
and conditions currently promised by gene therapy and other biotech-oriented
medical miracles can potentially touch us all. Our lives may, quite literally, be
changed. Environmental biotechnology, by contrast, deals with far less apparently
dramatic topics and, though their importance, albeit different, may be every bit
as great, their direct relevance is far less readily appreciated by the bulk of
the population. Cleaning up contamination and dealing rationally with wastes
is, of course, in everybody's best interests, but for most people, this is simply
addressing a problem which they would rather had not existed in the first place.
Even for industry, though the benefits may be noticeable on the balance sheet, the
likes of effluent treatment or pollution control are more of an inevitable obligation
than a primary goal in themselves. In general, such activities are typically funded
on a distinctly limited budget and have traditionally been viewed as a necessary
inconvenience. This is in no way intended to be disparaging to industry; it simply
represents commercial reality.
In many respects, there is a logical fit between this thinking and the aims
of environmental biotechnology. For all the media circus surrounding the grand
questions of our age, it is easy to forget that not all forms of biotechnology
involve xenotransplantation, genetic modification, the use of stem cells or cloning.