Biomedical Engineering Reference
In-Depth Information
(Adapted from: Giroux et al., 2005).
Figure 16. A Scintigraphic study showing that the Vianase Device produces greater
material deposition in the nasal cavity (a) compared to a spray pump (b) whilst a
conventional nebulizer localized the deposition in the frontal region of the nose (c).
Delivery of nasal aerosols as dry powders may prolong the residence time
in the nasal cavity and hence enhance the systemic absorption of drugs. An
OptiNose breath-actuated bi-directional nasal delivery device (OptiNose AS,
Norway) has been developed for nasal delivery of powdered aerosol
formulations (Figure 17). The OptiNose is a V-shaped device with two open
ends, one is inserted in the mouth (mouthpiece) after loading the dry powder
