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OH
H
O
O
O
B29N
ε
-desB30 human insulin
OH
B29N
ε
-desB30 human insulin
O
OH
Figure 7.8 Structures of NN344 B29N
e
-lithocholyl-g-glutamyl desB30 human
insulin and 0377 B29N
e
-lithocholyl desB30 human insulin
Figure 7.9 The 0377 3D structure (1UZ9) showing hexamer-hexamer interactions.
The zoomed box shows the cross-hexamer binding of the B29N
e
-lithocholyl residue in
a pocket in the opposing hexamer, lined by among others ProB28 and TyrB26. A phenyl-
phenyl stacking interaction is clear between B1s from opposing hexamers. The residual
lithocholyl residues that seemingly protrude into open space are in fact bound to neigh-
bouring hexamers, which were removed for clarity (see colour Plate 6)
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