De Novo Design of Proteins - Peptide and Protein Design for Biopharmaceutical Applications - page 217

K

KK

E

G

b

f

L

L

e

G

EE

c

K

E

L

E

a

g

E

g L

L

EKG

c d

L

d L L

K

f

K G

a

L L

L

b

a

L L

e L

L

E

e

d

L

K L

L

b

E K

g

E

K

f

c

G

G

E

K

E

A

K

K

KK

E

G

b

f

L

L

e

G

EE

c

K

E

L

E

a

g

E L

g

L

E K G

d

c

L

d LL

K

K G f

a

LL

L

b

d

GK E

e L

L

E g

a

L

L

K

L

c

EE

e

L

L

f

b

K

K

B

KG

E

Figure 6.5 Helical wheel presentation of an amphipathic sequence in a triple-helical
arrangement (a 1 B, GEL a EELLKKLKELLKG). The parallel topology (a) has three
identical e - g interactions, wheras the antiparallel topology (b) has three different
interfaces, e - e , e - g and g - g . Created with DrawCoil 1.0