Biomedical Engineering Reference
In-Depth Information
[302] D. Y. Wang, W. Liao and P. S. Arora, Binding properties of artificial a helices derived
from a hydrogen-bond surrogate: Application to Bcl-x L , Angew.Chem.Int.Edit ., 44,
6525-6529 (2005).
[303] D. Wang, M. Lu and P. S. Arora, Inhibition of HIV-1 fusion by hydrogen-bond-
surrogate-based alpha helices, Angew.Chem.Int.Edit ., 47, 1879-1882 (2008).
[304] C. A. Hutton and P. A. Bartlett, Preparation of diazabicyclo[4.3.0]nonene-based
peptidomimetics, J.Org.Chem ., 72, 6865-6872 (2007).
[305] R. E. Austin, R. A. Maplestone, A. M. Sefler, K. Liu, W. N. Hruzewicz, C. W. Liu,
H. S. Cho, D. E. Wemmer and P. A. Bartlett, Template for stabilization of a peptide
alpha-helix: Synthesis and evaluation of conformational effects by circular dichro-
ism and NMR, J.Am.Chem.Soc ., 119, 6461-6472 (1997).
[306] D. C. Horwell, W. Howson, G. S. Ratcliffe and H. M. G. Willems, The design of
dipeptide helical mimetics: The synthesis, tachykinin receptor affinity and confor-
mational analysis of 1,1,6-trisubstituted indanes, Bioorgan.Med.Chem ., 4, 33-42
(1996).
[307] E.
Jacoby,
Biphenyls
as
potential
mimetics
of
protein
alpha-helix,
Bioorg.Med.Chem.Lett ., 12, 891-893 (2002).
[308] B. P. Orner, J. T. Ernst and A. D. Hamilton, Toward proteomimetics: Terphenyl
derivatives as structural and functional mimics of extended regions of an alpha-
helix, J.Am.Chem.Soc ., 123, 5382-5383 (2001).
[309] H. Yin, G. Lee, K. A. Sedey, O. Kutzki, H. S. Park, B. P. Orner, J. T. Ernst, H. G. Wang,
S. M. Sebti and A. D. Hamilton, Terphenyl-based bak BH3 a-helical proteomimetics as
low-molecular-weight antagonists of Bcl-x L , J.Am.Chem.Soc ., 127, 10191-10196
(2005).
[310] O. Kutzki, H. S. Park, J. T. Ernst, B. P. Orner, H. Yin and A. D. Hamilton,
Development of a potent Bcl-x L antagonist based on alpha-helix mimicry,
J.Am.Chem.Soc ., 124, 11838-11839 (2002).
[311] H. Yin, G. I. Lee, H. S. Park, G. A. Payne, J. M. Rodriguez, S. M. Sebti and
A. D. Hamilton, Terphenyl-based helical mimetics that disrupt the p53/HDM2
interaction, Angew.Chem.Int.Edit ., 44, 2704-2707 (2005).
[312] J. T. Ernst, O. Kutzki, A. K. Debnath, S. Jiang, H. Lu and A. D. Hamilton, Design of
a protein surface antagonist based on alpha-helix mimicry: Inhibition of gp41
assembly and viral fusion, Angew.Chem.Int.Edit ., 41, 278 ff. (2001).
[313] I. C. Kim and A. D. Hamilton, Diphenylindane-based proteomimetics reproduce
the projection of the i , i þ 3, i þ 4, and i þ 7 residues on an a-helix, Org.Lett ., 8,
1751-1754 (2006).
[314] J. T. Ernst, J. Becerril, H. S. Park, H. Yin and A. D. Hamilton, Design and applica-
tion of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy:
Antagonism of the bak BH3/Bcl-x L complex, Angew.Chem.Int.Edit ., 42, 535 ff.
(2003).
[315] J. M. Ahn and S. Y. Han, Facile synthesis of benzamides to mimic an alpha-helix,
Tetrahedron Lett ., 48, 3543-3547 (2007).
[316] H. Yin and A. D. Hamilton, Terephthalamide derivatives as mimetics of the helical
region of Bak peptide target Bcl-x L protein, Bioorg.Med.Chem.Lett ., 14, 1375-
1379 (2004).
[317] J. M. Rodriguez and A. D. Hamilton, Intramolecular hydrogen bonding allows
simple enaminones to structurally mimic the i , i þ 4, and i þ 7 residues of an a-helix,
Tetrahedron Lett ., 47, 7443-7446 (2006).
Search WWH ::




Custom Search