Biomedical Engineering Reference
In-Depth Information
Fig. 4.2.
Two-dimensional
geometrical
description:
heart
domain
Ω
H
,
torso
domain
Ω
T
(extramyocardial regions), heart-torso interface
Σ
and torso external boundary
Γ
ext
The resulting coupled system can be formulated in terms of
V
m
,
u
e
,
w
and the
torso potential
u
T
as follows (see, e.g., [53, 61]):
⎨
⎩
∂
t
w
+
g
(
V
m
,
w
)=
0
,
in Ω
H
×
(
0
,
T
)
,
χ
m
∂
t
V
m
+
I
ion
(
V
m
,
w
)
−
div
(
σ
i
∇
V
m
)
−
div
(
σ
i
∇
u
e
)=
I
app
in Ω
H
×
(
0
,
T
)
,
−
div
(
σ
i
+
σ
e
)
∇
u
e
−
div
(
σ
i
∇
V
m
)=
0 nΩ
H
×
(
0
,
T
)
,
−
div
(
σ
T
∇
u
T
)=
0 nΩ
T
×
(
0
,
T
)
,
(4.8)
σ
T
∇
u
T
·
n
T
=
0 n
Γ
ext
×
(
0
,
T
)
,
σ
i
∇
V
m
·
n
+
σ
i
∇
u
e
·
n
=
0 nΣ
×
(
0
,
T
)
,
u
T
=
u
e
on
Σ
×
(
0
,
T
)
,
σ
e
∇
u
e
·
n
=
−
σ
T
∇
u
T
·
n
T
on
Σ
×
(
0
,
T
)
,
V
m
,
w
w
0
. The boundary condition on
with the initial conditions
V
m
|
=
|
=
t
=
0
t
=
0
def
=
∂Ω
Γ
\
Σ
states that no current can flow from the external torso surface (see
ext
T
Fig. 4.2).
The coupled system of Eqs. (4.8) is often known in the literature as the
full bido-
main
or
coupled bidomain
model (see, e.g., [14, 61]). It can be considered as the
“gold standard” in the modelling of the ECG (see, e.g., [38, 53, 61]).
Remark 2.
A common approach to reduce the computational complexity of (4.8)
consists of uncoupling the computation of
from that of
u
T
, by neglecting
the electrical torso-to-heart feedback (see, e.g., [14, 38, 50]). Thus, the coupling
conditions (4.7) are replaced by
(
w
,
V
m
,
u
e
)
u
T
=
u
e
on
Σ
,
(4.9)
σ
e
∇
u
e
·
n
=
0 n
Σ
,