Molecular Dynamics Simulations of the Ribosome - Biophysical Approaches to Translational Control of Gene Expression - page 53

Fig. 3.3 50S large ribosomal subunit

Fig. 3.4 tRNA binding sites on small subunit. Aminoacyl tRNA ( yellow ) bound to A site. Peptidyl
tRNA ( red ) bound to P site. Exit tRNA ( orange ) bound to E site

With regard to medical applications, the bacterial ribosome is a major target of
antibiotics. Approximately 50 % of antibiotics used in US hospitals target the ribo-
some (Mankin 2006 ). Although the molecular mechanism of several new antibiotic