Riboproteomic Approaches to Understanding IRES Elements - Biophysical Approaches to Translational Control of Gene Expression - page 103

Table 6.1 RNA-binding proteins interacting with viral IRES
ITAF IRES activity Targets Protein function

PTB Stimulation FMDV, EMCV,

TMEV, PV,
H RV, H AV,
EV71, HCV

Splicing, RNA stability, RNA
localization

PCBP2 Stimulation PV, HRV, HAV,

CVB3, EV71,
FMDV a , EMCV a ,
HCV

RNA stability, translation

SRp20 Stimulation PV Splicing

Nucleolin Stimulation PV, HRV, FMDV,

HCV, HIV-1

rRNA maturation, transport

FBP2 Repressor EV71 RNA stability

FBP1 Stimulation EV71 Translation control

Gemin5 Repressor FMDV, HCV snRNAs biogenesis, translation

hnRNP K - FMDV, EV71 RNA stability, translation

hnRNPU - FMDV, HIV-1 RNA stability

DHX9 - HRV, FMDV, HCV RNA helicase

DDX1 - FMDV RNA helicase

DDX3 Stimulation HCV, HIV-1 RNA helicase

Unr Stimulation PV, HRV, EV71,

HCV

Translation control

Ebp1/PA2G4/ITAF 45 Stimulation FMDV, EMCV a ,

EV71

Transcription regulator

DRBP76:NF45 Repressor HRV, HCV Transcription, RNA stability

G3BP - FMDV Stress granules

RACK1 - HCV Ribosomal subunits joining

IGF2BP1/IMP1 Stimulation EV71 a , HCV RNA stability, translation

La Stimulation PV, EMCV,

HAV b , HCV

Transcription, translation
control

hnRNPA1/A2 Stimulation EV71, HCV, HIV-1 RNA processing, translation

NSAP1/hnRNP Q Stimulation HCV RNA processing, translation

hnRNP L, D Stimulation HCV, HIV-1 RNA stability, translation

GAPDH Repressor HAV RNA transport, translation

control

YB-BP1 - HCV Transcription, RNA stability

Tubulin, tropomyosin - HCV, HIV-1 Cytoskeleton

HuR Stimulation HCV, HIV-1 b RNA stability

hRIP Stimulation HIV-1 RNA localization, export

Sam68 Repressor HCV, HIV-1 Splicing regulator

Activ transc coact. p15 - HIV-1 Transcription regulator

DNA topoisomerase - HIV-1 DNA replication

Mt-ssb - HIV-1 Single-stranded DNA-binding

DNA-binding protein A - HIV-1 DNA replication

a No effect
b Supression