Inhibition of Fungal Biofilms - Antibiofilm Agents: From Diagnosis to Treatment and Prevention - page 275

Fig. 3 The C. albicans
nano-biofilm chip for high-
throughput applications
6 Summary
There is an increasing recognition of the role that biofilms play during fungal
infections, further complicating antifungal treatment for these already difficult to
treat infections. The area of fungal biofilm research has witnessed strong growth in
the last two decades, with significant technological advances, the application of
powerful molecular technologies, and a vigorous translational emphasis. Hopefully
in the not so distant future, we should be able to harness this knowledge for the
development of new therapeutic strategies to conquer this formidable challenge.
Acknowledgments Biofilm work in the laboratory is funded by Grant numbered 1R01DE023510
from the National Institute of Dental & Craniofacial Research (to JLL-R) and by the Army
Research Office of the Department of Defense under Contract No. W911NF-11-1-0136. Infectious
diseases-related work in the A.K.R. laboratory is funded by NIH (SC1HL112629). CGP and AS
acknowledge the receipt of predoctoral fellowships from American Heart Association, numbered
51PRE30004 and 13PRE17110093. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript, and the content is solely the
responsibility of the authors.
References
Al-Fattani MA, Douglas LJ (2006) Biofilm matrix of Candida albicans and Candida tropicalis:
chemical composition and role in drug resistance. J Med Microbiol 55(Pt 8):999-1008
Andes D, Nett J, Oschel P, Albrecht R, Marchillo K, Pitula A (2004) Development and charac-
terization of an in vivo central venous catheter Candida albicans biofilm model. Infect Immun
72(10):6023-6031
Bachmann SP, VandeWalle K, Ramage G, Patterson TF, Wickes BL, Graybill JR, Lopez-Ribot JL
(2002) In vitro activity of caspofungin against Candida albicans biofilms. Antimicrob Agents
Chemother 46(11):3591-3596
Bachmann SP, Ramage G, VandeWalle K, Patterson TF, Wickes BL, Lopez-Ribot JL (2003)
Antifungal combinations against Candida albicans biofilms in vitro. Antimicrob Agents
Chemother 47(11):3657-3659
Baillie GS, Douglas LJ (1998a) Effect of growth rate on resistance of Candida albicans biofilms to
antifungal agents. Antimicrob Agents Chemother 42(8):1900-1905