Biomedical Engineering Reference
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improve. Despite these successes, many areas outlined herein are still in need of
further improvement as the field continues to mature. Perhaps most importantly,
only a select few of the current in vitro biofilm-related discoveries have transitioned
to animal model confirmation. Due to the high level of variability in biofilm results,
it will be critically important to continue testing new treatment approaches in
relevant animal models of biofilm infection. Altogether, the recent advances in
biofilm knowledge hold great promise for developing effective approaches for
treating some of the devastating
S. aureus
chronic infections.
Acknowledgments
C.B.R. was supported by NIH Training Grants GM008365 and DE023520. J.
M.M was supported by NIH T32 Training Grant No. AI07511. This work was supported by grant
AI083211 (Project 3 to ARH) from the National Institute of Allergy and Infectious Diseases.
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