Staphylococcus aureus Biofilm Formation and Inhibition - Antibiofilm Agents: From Diagnosis to Treatment and Prevention - page 236

Table 2 Synthetic and natural product small molecules that inhibit S. aureus biofilms
Process or agent Anti-biofilm mechanism References

Natural products
Cis -2-decanoic acid

Unknown Davies and Marques

( 2009 )

Tannic acid Induction of IsdA and potential

modulation of cell wall

Lee et al. ( 2013 ), Payne
et al. ( 2013 )

Ellagic acid Unknown Quave et al. ( 2012 )

Magnolol Inhibition of autolysis and eDNA

release

Wang et al. ( 2011a )

4,5-Disubstituted-2-
aminoimidazole-triazole
conjugates

Zinc-chelation Su et al. ( 2011 )

N -acetyl- L -cysteine Unknown Drago et al. ( 2013 )

Synthetic
Chelators

Metal chelation Venkatesh et al. ( 2009 )

Aryl rhodanines Inhibition of attachment Opperman et al. ( 2009 )

Fig. 3 Structures of natural product inhibitors of S. aureus biofilm formation. Representative
examples of bacterial-derived compounds are shown along with plant- or marine-derived
compounds