The Role of Quorum Sensing in Biofilm Development - Antibiofilm Agents: From Diagnosis to Treatment and Prevention - page 97

Table 1 Examples of QS-dependent biofilm-related processes in different microbes

QS-regulated,
biofilm-related
process

Implicated QS genes
and/or signals Microorganism References

Aeromonas
hydrophila

ahyI
Endogenous signal:
C 4 -HSL

Maturation Lynch et al. ( 2002 )

Bacillus cereus plcR , papR

Endogenous signal: AI-2

Promotes dispersal Hsueh et al. ( 2006 ),
Auger et al. ( 2006 )

Burkholderia cepacia cciI/R , cepI/R
Endogenous signals:
C 6 -HSL, C 8 -HSL

Attachment
maturation

Tomlin et al. ( 2005 ),
Huber et al. ( 2001 ,
2002 )

Campylobacter jejuni luxS

Endogenous signal: AI-2

Not defined Reeser et al. ( 2007 )

Candida albicans Endogenous signal:

farnesol; exogenous
signals: 3OC 12 -HSL,
BDSF, cis-2-
decenoic acid, CSP,
SDSF, AI-2

Promotes dispersal;
promote hyphal
formation

Ramage et al. ( 2002 ),
Hogan et al. ( 2004 ),
Davies and Marques
( 2009 ),
Boon et al. ( 2008 ),
Jarosz et al. ( 2009 ),
Vilchez et al. ( 2010 ),
Bamford et al. ( 2009 )

Helicobacter pylori luxS

Endogenous signal: AI-2

Negatively regu-
lates attachment

Cole et al. ( 2004 )

Klebsiella pneumonia luxS
Endogenous signal:
AI-2; exogenous sig-
nal: cis-2-decenoic
acid

Development of
microcolonies;
promotes
dispersal

Balestrino et al. ( 2005 ),
Davies and Marques
( 2009 )

Listeria
monocytogenes

luxS; agrA , C and D Not defined;

attachment

Challan Belval
et al. ( 2006 ), Rieu
et al. ( 2007 )

Lactobacillus
plantarum

lam operon Attachment Sturme et al. ( 2005 )

Pantoea stewartii esaI/R

Endogenous signal:
3OC 6 -HSL

Negatively regu-
lates attachment

von Bodman
et al. ( 1998 ),
Koutsoudis
et al. ( 2006 )

Pseudomonas
aeruginosa

lasI/R
Endogenous signals:
3OC 12 -HSL; cis-2-
decenoic acid; exog-
enous signal: DSF

Maturation; pro-
motes dispersal;
maturation

Davies et al. ( 1998 ),
Davies and Marques
( 2009 ), Ryan
et al. ( 2008 )

Rhodobacter
sphaeroides

cerI/R
Endogenous signal:7,8-
cis- N -(tetradecenoyl)
homoserine lactone

Negatively
regulates
aggregation

Puskas et al. ( 1997 )

Serratia liquefaciens swrI

Endogenous signals:
C 4 -HSL, C 6 -HSL

Maturation Labbate et al. ( 2004 )

Serratia marcescens swrI

Endogenous signals:
C 4 -HSL

Attachment Labbate et al. ( 2007 )