Chemistry Reference
In-Depth Information
Selective
growth
Bifidobacterium
dominated microbiota
Lactose
derivatives
intestinal lumen
M cell
colonocytes
DC
DC
Tolerogenic immune environment
T
Tr
Suppression
of allergenic
Th2 responses
IL-10, TGF-
β
lamina propria
Th2
IL-12
IFN-
γ
Th1
Figure 5.8.
Proposed mechanism by which prebiotic lactose derivatives assist in the establish-
ment of a tolerogenic immune environment in the gut leading to correct immune programming to
dietary antigens and fewer allergies.
Increased faecal bulk and
rate of Intestinal transit
carbohydrate
fermentation
Lactose
derivatives
SCFA
lower intestinal pH
butyrate - trophic
and anti-neoplastic
effects on epithelium
antagonism of
putrefactive bacteria
and activities
fewer genotoxic and
mutagenic microbial
metabolites
Immune
modulation
Figure 5.9.
Impact of lactose derivatives on reducing purported risk factors for colorectal
cancer.
