Agriculture Reference
In-Depth Information
Toxicology and Mode of Action
The mode of action of the members of this group appears to be the inhi-
bition of the enzyme monoamine oxidase. This inhibition leads to an accu-
mulation of toxic intermediates.
In a reported episode of occupational exposure to chlordimeform, several
workers developed hematuria. Hemorrhagic cystitis, probably due to chlorani-
line biodegradation products, was the source of the blood in the urine. Symp-
toms reported by the affected workers were: gross blood in the urine, painful
urination, urinary frequency and urgency, penile discharge, abdominal and back
pain, a generalized "hot" sensation, sleepiness, skin rash and desquamation, a
sweet taste, and anorexia. Symptoms persisted for 2-8 weeks after exposure
was terminated.
7.
Organosulfurs
Toxicology and Mode of Action
Propargite is an acaricide with residual action. Formulations are wettable
powders and emulsifiable concentrates.
Commercial Products include Omite, Comite, and Uniroyal D014.
Propargite exhibits very little systemic toxicity in animals. No systemic
poisonings have been reported in humans. However, many workers having
dermal contact with this acaricide have experienced skin irritation and possibly
sensitization in some cases. Eye irritation has also occurred. For this reason,
stringent measures should be taken to prevent inhalation or any skin or eye
contamination by propargite.
There is no readily available method for detecting absorption of propar-
gite.
8.
Substituted Ureas (Acylureas)
Toxicology and Mode of Action
These are haloaromatic substituted ureas which controls insects by im-
pairing chitin deposition in the larval exoskeleton. They are formulated in wetta-
ble powders, oil dispersible concentrates, and granules for in agriculture and
forestry and in settings where fly populations tend to be large, such as feed-
lots.
Table 5.8
Commercial products containing substituted ureas.
Active ingredient
Products
Diflubenzuron
Dimilin, Micromite
Teflubenzuron
Nomolt, Dart, Diaract
Triflumuron
Alsystin
Chlorfluazuron
Atabron, Jupiter
Hexaflumuron
Trueno, Consult
