Chemistry Reference
In-Depth Information
CO
2
CH
2
CO
2
CH
2
CH-CH
2
CH-CH
2
I
O
OCH
3
Q
+
I
-
ICH
3
CO
2
CH
2
CH-CH
2
I
O
-
Q
+
Fig.
8
.13
Polymethacrylate with
pendant iodomethyl groups.
N
N
N
N
N
N
N
Fig.
8
.14
Cross-linked poly(4-
vinylpyridine).
H
N
H
N
N
N
N
N
H
Fig.
8
.15
Polybenzimidazole.
Solid-phase synthesis (SPS) is now a powerful tool
in drug research for the accelerated production of
families of molecules to be screened, and several
topics, reviews and dedicated journals are now avail-
able [62-70]. This section thus will be devoted to
methods of performing (according to Fig. 8.1) a
discrete and unique transformation of a molecule
in solution with an excess of reagent immobilised
on an organic polymer. It should be recalled that
the interest for the organic chemist lies more in the
