Biomedical Engineering Reference
In-Depth Information
O
O
F
R'
CO
2
R
R'
CO
2
R
Selectfluor
®
n
n
MES buffer (pH = 5.5)
ee up to 74%
N
N
FIGURE 16.13
DNA-mediated enantioselective C-F bond formation.
16.5. SUMMARY
In the past several decades, DNA has been the focus of intense interest as the
repository of genetic information. The right-handed helix structure with its well-
defined geometry is now starting to claim a prominent position in the field of synthetic
organic chemistry with applications in molecule discovery. The ability of DNA to
translate information into synthetic molecules has led to new approaches for a wide
range of synthetically relevant reactions. As a consequence, we can anticipate the
growing importance of the DNA scaffold for the development of new synthetic tools,
which will most certainly be of common use in the near future by the entire synthetic
community for the preparation of complex bioactives.
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