DNA AS A TOOL FOR MOLECULAR DISCOVERY - Modern Tools for the Synthesis of Complex Bioactive Molecules - page 543

(a)

DNA library

Amplification/
Diversification

Chemical
translation

Selected/evolved molecule

Translated
conjugate library

Selection

(b)

Split

Chemistry

Pool

Split

FIGURE 16.7 (a) The DNA display approach. (b) A close look at the chemical translation
step. (See insert for color representation of this figure.)

groups have tried to exploit this property. The challenge in DNA-based asymmetric
catalysis is to perform a reaction in the vicinity of the helix, which provides the chiral
information to the reactive species, thus resulting in chiral discrimination. By analogy
with the hybrid metalloenzymes,

the DNA-based asymmetric catalysts should