Biomedical Engineering Reference
In-Depth Information
O
OMe
OMe
O
O
O
O
PhH, 120°C
sealed tube
H
I
B
O
O
OMe
O
O
O
OMe
94
97
100
(
rac
)-
104
(15%)
O
H
PdCl
2
(MeCN)
2
DMF, 50°C
darkness
O
OMe
(
rac
)-
105
(6%)
O
B
O
O
OMe
O
O
95
O
Pd(PPh
3
)
4
, THF
aq KOH, 80°C
Xylene, 150°C
darkness
H
H
O
OMe
OH
O
O
O
OMe
OMe
101
(
rac
)-
103
(4%)
(
rac
)-
104
(10%)
(
rac
)-
106
(9%)
Br
O
OMe
98
OMe
OMe
Cyclohexane
h
O
O
, rt
ν
H
(
rac
)-
107
(9%)
O
O
(
rac
)-
108
(4%)
O
2
, CHCl
3
, methylene blue, h
ν,
rt
O
O
O
O
O
O
Pd(PPh
3
)
4
, THF
aq KOH, 80°C
Br
MeOH, h
ν,
rt
MeOH, h
ν,
rt
B
O
O
O
O
OMe
O
OMe
O
OMe
OMe
(
rac
)-
109
(25%)
O
O
OMe
96
99
102
(
rac
)-
110
(18%)
(
rac
)-
111
(99% conversion)
Search WWH ::
Custom Search