Biomedical Engineering Reference
In-Depth Information
aware of the broad potential of these techniques. In addition, while thework presented
here does not replace the total synthesis of natural products, it does present a way in
which selected analogues can be produced with substantially less effort. In tandem
with total and semisynthesis, precursor-directed biosynthesis provides a means by
which to greatly expedite medicinal chemistry efforts related to natural products and
its utility will increase greatly in the coming years as the scientific community gains
more knowledge about the intricacies of natural product biosynthesis.
Acknowledgments
Our research on precursor-directed biosynthesis has been supported by a grant fromtheNIH (R01
GM 087934) to C. K. We thank Dr. Louise Charkoudian for critical reading of this manuscript.
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