Biomedical Engineering Reference
In-Depth Information
TABLE 7.4 Phase-Transfer-Catalyzed Enantioselective Epoxidation of Chalcone
O
O
catalyst
conditions
O
Ph
Ph
Ph
Ph
Yield
(%)
ee (%)
(Configuration)
Catalyst (mol%)
Conditions
Reference
30% H
2
O
2
aq, LiOH, Bu
2
O, 4
C
97
84
60
Br
-
OH
+
N
N
H
I
1d
(10 mol%)
KOCl aq, Toluene, -40
C
96
93
61
Br
-
+
H
N
O
N
Ph
6d
(10 mol%)
30% H
2
O
2
aq, 50% KOH aq,
i
-Pr
2
O, Span 20, rt
95
>99
62
2Br
-
OMe
OMe
+
+
H
H
N
N
F
HO
OH
N
N
52
(1 mol%)
(
continued
)
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