Biomedical Engineering Reference
In-Depth Information
NC
CO
2
t
-Bu
O
(
S
)-
41b
NC
CO
2
t
-Bu
(1 mol%)
+
Me
O
t
-Bu
Cs
2
CO
3,
Toluene,
-40°C, 5 h
Me
O
99%
O
t
-Bu
(
E
/
Z
= 6.7/1)
(ee = 93%)
O
O
O
O
(
S
)-
41c
(1 mol%)
+
CO
2
t
-Bu
Me
K
2
CO
3,
Et
2
O,
-40°C, 3 h
98%
CO
2
t
-Bu
(
E
/
Z
= 1.2/1)
(ee = 85-93%)
F
3
C
CF
3
Ar
-
Br
+
N
X
Ar =
CF
3
Ar
(
S
)-
41b
(X = O)
(
S
)-
41c
(X = NPh)
CF
3
SCHEME 7.19
O
Ph
Ph
(
S
)-
45
(3 mol%
)
O
+
O
PhCOOK
Toluene, -60°C, 24 h
97%
N
Boc
N
Boc
O
(ee = 99%)
Ph
Ph
Ph
NO
2
(
S
)-
46a
(1 mol%
)
NO
2
+
O
O
Ph
H
2
O/Toluene (10:1)
0°C, 2 h
93%
N
Boc
N
Boc
(dr = 97:3)
(ee = 90%)
without base
Ar
Ar
Ar
-
-
Br
OH
Br
+
+
Bu
Bu
P
N
O
OH
Ar
Ar
Ar
(
S
)-
45
(Ar = 3,5-(CF
3
)
2
-C
6
H
3
)
(
S
)-
46a
(Ar = 3,5-(CF
3
)
2
-C
6
H
3
)
SCHEME 7.20
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