GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS - Modern Tools for the Synthesis of Complex Bioactive Molecules - page 150

H

HO

O

HO

HO

O

O

H

O

HO O

OH

H

HO O

O

HO O

HO OH

O

HO O O

OH

OH

O

O

O O

HO

HO

OH

OH

Lobatoside E 250

SCHEME 4.71b Structure of lobatoside E.

noted that no examples have been reported in the literature regarding the synthesis of a
natural product or a biologically active compound featuring an enantioselective
reaction that uses a chiral gold catalyst. However, the developments recently made
in this field should strongly influence future applications [76]. In addition, the latest
discoveries concerning the possibility to combine gold-catalyzed nucleophilic addi-
tions and coupling reactions, by cycling between Au(I) and Au(III) oxidation
states [77], should pave the way to the development of evenmore complex transforma-
tions that should find applications in total synthesis.

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