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[66] Jones, G.B.; Mathews, G.E. Bifunctional antitumor agents: a DNA interactive
enediyne from the pyrrolo[9,10-b]phenanthrene template. Bioorg. Med. Chem.
Lett. 1997, 7, 745-748; Jones, G.B.; Mathews, J.E. Bifunctional antitumor
agents. Derivatives of pyrrolo[9,10-b]phenanthrene — A DNA intercalative
delivery template. Tetrahedron 1997, 53, 14599-14614.
[67] Bunnage, M.E.; Nicolaou, K.C. The oxide anion accelerated retro-Diels-Alder
reaction. Chem. Eur. J. 1997, 3, 187-192.
[68] Dai, W.M.; Lai, K.W.; Wu, A. X.; Hamaguchi, W.; Lee, M.Y. H.; Zhou, L.;
Ishii, A.; Nishimoto, S. DNA cleavage potency, cytotoxicity, and mechanism
of action of a novel class of enediyne prodrugs. J. Med. Chem. 2002, 45,
758-761.
[69] Semmelhack, M.F.; Neu, T.; Foubelo, F. Arene 1,4-Diradical formation from
o-dialkynylarenes. Tetrahedron Lett. 1992, 33, 3277-3280.
[70] Taneko, T.; Takahashi, M.; Hirama, M. Benzannelation alters the rate limiting
step in enediyne cycloaromatization. Tetrahedron Lett. 1999, 40, 2015-2018.
[71] Boger, D.L.; Zhou, J. CDPI 3 -enediyne and CDPI 3 -EDTA conjugates: a new
class of DNA cleaving agents. J. Org. Chem. 1993, 58, 3018-3024.
[72] Nicolaou, K.C.; Liu, A.; Zeng, Z.; McComb, S. Redox-controlled Bergman
cycloaromatizations. Designed enediynes with DNA-cleaving properties and
antitumor activity. J. Am. Chem. Soc. 1992, 114, 9279-9282.
[73] Choy, N.; Blanco, B.; Wen, J.; Krishnan, A.; Russell, K.C. Photochemical and
thermal Bergman cyclization of a pyrimidine enediynol and enediynone.
Organic Lett. 2000, 2, 3761-3764.
[74] Singh, R.; Just, G. The synthesis of a 10-membered benzo-oxadiyne ring.
Tetrahedron Lett. 1990, 31, 185-188.
[75] Basak, A.; Bdour, H.M.; Shain, J.C.; Mandal, S.; Rudra, K.R.; Nag, S. DNA-
cleavage studies on N-substituted monocyclic enediynes: Enhancement of
potency by incorporation of intercalating or electron poor aromatic ring and
subsequent design of a novel phototriggerable acyclic enediyne. Bioorg. Med.
Chem. Lett. 2000, 10, 1321-1325.
[76] Suzuki, I.; Shigenaga, A.; Manabe, A.; Nemoto, H.; Shibuya, M. Synthesis,
reactions and DNA damaging abilities of 10-membered enediyne-sulfone and
related compounds. Tetrahedron 2003, 59, 5691-5704.
[77] Banfi, L.; Guanti, G.; Rasparini, M. Intramolecular opening of b -lactams with
amines as a strategy toward enzymatically or photochemically triggered
activation of lactenediyne prodrugs. Eur. J. Org. Chem. 2003, 1319-1336.
[78] Semmelhack, M.F.; Gu, Y.; Ho, D.M. A new framework for the
cycloaromatization of enediynes under mild conditions. Tetrahedron Lett.
1997, 38, 5583-5586.
[79] Semmelhack, M.F.; Jaskowski, M.; Sarpong, R.; Ho, D.M. A simple synthesis
and evaluation of the bicyclo[8.3.0]enediyne framework. Tetrahedron Lett.
2002, 43, 4947-4950.
[80] Wang, J.; De Clercq, P.J. Estramycins: a new diyl precursor family derived
from estradiol. Angew. Chem., Int. Ed. Engl. 1995, 34, 1749-1752.
[81] Banfi, L.; Guanti, G. Synthesis of a new lactenediyne scaffold equipped with
three handles. Tetrahedron Lett. 2002, 43, 7427-7429.
[82] Banfi, L.; Guanti, G. Synthesis of intramolecularly activated lactenediynes and
evaluation of their activity against plasmid DNA. Eur. J. Org. Chem. 2002,
3745-3755.
 
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