Agriculture Reference
In-Depth Information
tAble 2.1
selected membrane-bound Peptidases Active in food digestion in human small Intestine
name
Abbreviation
chromosome
subunits
functions
divergence
ec
Enterokinase
ENTK
21q21
Yes
Activates pancreatic proteases
Bacteria ~ 2 bya
3.4.21.9
Dipeptidyl-peptidase IV
DPP IV
2q24
No
Degrades GLP-1
CD26
Archaea ~ 3.5 bya
3.4.14.5
Aminopeptidase N
AMPN
15q25
Yes; Zn
Degrades enkephalins
CD13
Archaea ~ 3.5 bya
3.4.11.2
Aminopeptidase A
APA
4q25
Yes; Zn
Degrades ACE
CD249
Archaea ~ 3.5 bya
3.4.11.7
X-Pro aminopeptidase 2
XPNPEP2
Xq25
Yes; Mn
isoforms
Degrades bradykinin
Archaea ~ 3.5 bya
3.4.11.9
GGT1-6
20p11.1, 20q11.22,
22q11.21, 22q11.23
Yes; isoforms
Degrades GSH
CD224
Archaea ~ 3.5 bya
2.3.2.2
γ-Glutamyl transpeptidase
Note:
Named lymphocyte antigens are shown in
bold
. bya, billion years ago. GLP-1, glucagon-like peptide 1; Enkephalins, endogenous opioids; ACE, angio-
tensin1-converting enzyme; GSH, L-gamma-glutamyl-L-cysteinyl-glycine.
