Biology Reference
In-Depth Information
3
RNA Editing by Mammalian
ADARs
Marion Hogg, Simona Paro, Liam P. Keegan,
and Mary A. O'Connell
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine,
Western General Hospital, Edinburgh, United Kingdom
I. Introduction
II. Structure and Evolution of the CDA Domain
III. The ADAs That Act on RNA Family
A. ADAR1
B. ADAR2
C. ADAR3
IV. Testis-Expressed Nuclear RNA-Binding Protein
V. RNA Binding by ADARs
VI. Secondary Structures of RNA-Editing Substrates
VII. Transcripts Edited by ADARs
VIII. Searches for Mammalian Transcripts Edited by ADARs
IX. Consequences of Inosine in Transcripts
X. Inosine-Containing RNA Regulates Gene Expression in
trans
XI. Editing and RNA Interference
XII. ADAR and Disease
XIII. ADAR2 Protects Against Neuronal Degeneration Following
Ischemic Insult
XIV. ADAR2 as a “Neuronal Gatekeeper”
XV. ADAR and Alternative Splicing
XVI. Coordination of Editing and Alternative Splicing
XVII. Conclusion
Acknowledgments
References
