Molecular Signaling: How Do Axons Die? - Advances in Genetics - page 198

Table 5.2. ( Continued )

Protein Context Related deficiency in nulls/roles of protein Reference

Scn8a Conditional null mouse Impaired motor function Levin et al. (2006)

Scn9a Human null mutations Insensitivity to pain Cox et al. (2006)

Sir2 Adult fly comp. heterozygote Avery et al. (2009)

Sod2 Mouse conditional null Misawa et al. (2006)

Syntaphilin Null mouse Low mitochondrial density, short-term facilitation Kang et al. (2008)

-Synuclein Spontaneous mouse null Specht and Schoepfer (2004)

Synaptotagmin Null neonatal mouse and null early adult
Drosophila

Synaptic vesicle depletion, defective calcium-
dependent release

Geppert et al. (1994), Loewen et al.

(2001)

Tau Null mouse Exacerbates Npc1 and Map1b phenotypes Dawson et al. (2001)

The table lists proteins with prominent roles in axonal or neuronal function that are dispensable for axon survival, at least in the experimental system
indicated.