Molecular Signaling: How Do Axons Die? - Advances in Genetics - page 197

Table 5.2. Proteins Whose Functional Loss Does Not Cause Axon Degeneration

Protein Context Related deficiency in nulls/roles of protein Reference

App Null mouse Reduced synaptic vesicle density Wang et al. (2005)

Ataxin 3 Null mouse Increased ubiquitination in the brain Schmitt et al. (2007)

Bace Null mouse Hypomyelination Willem et al. (2006)

Calpain 1 Null mouse Calpain activated in Wallerian degeneration Grammer et al. (2005)

Caspase 6 Null mouse Necessary for some forms of axon degeneration Zheng et al. (1999)

Enhanced neuronal NAD þ levels Cd38 Null mouse Sasaki et al. (2009)

EphA4 Null mouse Effects on axon regeneration Goldshmit et al. (2004)

Erk5 Conditional null mouse Role in retrograde survival signaling Wang and Tournier (2006)

Imac/kinesin 3 Mutant Drosophila embryo Synaptogenesis defects Pack-Chung et al. (2007)

Jip1 Null mouse Protects from excitotoxic stress Whitmarsh et al. (2001)

Jnk2 Null mouse Protects from apoptosis Ries et al. (2008)

Jnk3 Null mouse Protected from excitotoxicity Yang et al. (1997)

K v 1.1 Null mouse Increased excitability, epilepsy Smart et al. (1998)

Milton Drosophila second instar Absence of axonal mitochondria Stowers et al. (2002)

Miro Drosophila third instar Very few axonal mitochondria Guo et al. (2005)

Nefh Null mouse Increased microtubule density Zhu et al. (1998)

Nefl Null mouse Reduced caliber Zhu et al. (1997)

Nefm Null mouse Reduced caliber Elder et al. (1998)

Nogo66
receptor

Null mouse Enhanced axon growth Kim et al. (2004)

Nnos Null mouse Delayed axon regeneration Keilhoff et al. (2002)

p110 Kinase dead knockin mouse Poor axon regeneration Eickholt et al. (2007)

Presenilin 1 Conditional null mouse Inhibits amyloid pathology Dewachter et al. (2002)

Presenilin 2 Null mouse Donoviel et al. (1999)

Rab3 Quadruple null mouse Evoked synaptic release deficiency Schluter et al. (2004)

Scn2b Null mouse Reduced severity in EAE O'Malley et al. (2009)

( Continues )