Biology Reference
In-Depth Information
5
Molecular Signaling: How Do
Axons Die?
Michael Coleman
The Babraham Institute, Babraham, Cambridge, United Kingdom
I. Introduction
II. Axonal Transport and How to Block It
A. Road closed! General defects in axonal transport
B. Traffic restrictions: Specific axonal transport defects
C. One-way street! Unidirectional transport impairment
D. Banned from driving: Cargo-specific defects
E. Faulty signals
F. Traffic congestion: Partial blockages and axonal swellings
G. Reduced traffic flow: Ageing and decline
H. No parking! Could increased axonal transport be too much
of a “good” thing?
III. The Essentials of Axon Survival
IV. Take It or Leave It: What Axons Do Not Need to Survive
V. Protein Turnover Fast and Slow
VI. Axonal Protein Synthesis
VII. Anterograde Survival Signaling
VIII. Adhesion Molecules
IX. Life After (Cell) Death: The Wld
S
Phenotype
X. Summary: Axonal Transport and Axon Survival Signaling
Acknowledgments
References
