Biology Reference
In-Depth Information
1
Drosophila Models of
Parkinson's Disease
Alexander J. Whitworth
MRC Centre for Developmental and Biomedical Genetics, Department of
Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
I. Introduction
II. Drosophila as a Model Organism
A. Advantages and limitations of Drosophila to model PD
B. The neuroanatomy and function of DA neurons
in Drosophila
III. Dominant Traits
A.
-Synuclein models
B. LRRK2
IV. Recessive Traits
A. Parkin
B. DJ-1
C. PINK1
D. Omi/HtrA2
V. Function of the PINK1/Parkin Pathway
VI. Convergent Therapeutic Approaches
VII. Conclusions
Acknowledgments
References
Search WWH ::




Custom Search