The Regenerative Activity of Interleukin-6 - Tissue-Protective Cytokines: Methods and Protocols - page 73

50. Becker C et al (2004) TGF-beta suppresses
tumor progression in colon cancer by inhibi-
tion of IL-6 trans-signaling. Immunity
21:491-501
51. Becker C et al (2005) IL-6 signaling pro-
motes tumor growth in colorectal cancer. Cell
Cycle 4:217-220
52. Matsumoto S et al (2010) Essential roles of
IL-6 trans-signaling in colonic epithelial cells,
induced by the IL-6/soluble-IL-6 receptor
derived from lamina propria macrophages, on
the development of colitis-associated prema-
lignant cancer in a murine model. J Immunol
184:1543-1551
53. Lo CW et al (2011) IL-6 trans-signaling in
formation and progression of malignant ascites
in ovarian cancer. Cancer Res 71:424-434
54. Lesina M et al (2011) Stat3/Socs3 activation
by IL-6 transsignaling promotes progression
of pancreatic intraepithelial neoplasia and
development of pancreatic cancer. Cancer
Cell 19:456-469
55. Scheller J et al (2011) The pro- and anti-
inflammatory properties of the cytokine inter-
leukin-6.

65. Nechemia-Arbely Y et al (2011) Early hepato-
cyte DNA synthetic response posthepatec-
tomy is modulated by IL-6 trans-signaling
and PI3K/AKT activation. J Hepatol
54:922-929
66. Nechemia-Arbely Y et al (2008) IL-6/IL-6R
axis plays a critical role in acute kidney injury.
J Am Soc Nephrol 19:1106-1115
67. Chalaris A et al (2010) Critical role of the
disintegrin metalloprotease ADAM17 for
intestinal inflammation and regeneration in
mice. J Exp Med 207:1617-1624
68. Garbers C et al (2011) Species specificity of
ADAM10 and ADAM17 proteins in interleu-
kin-6 (IL-6) trans-signaling and novel role of
ADAM10 in inducible IL-6 receptor shed-
ding. J Biol Chem 286:14804-14811
69. Chalaris A et al (2007) Apoptosis is a natu-
ral stimulus of IL6R shedding and contrib-
utes to the proinflammatory trans-signaling
function of neutrophils. Blood 110:
1748-1755
70. Matsushita K et al (2005) Interleukin-6/sol-
uble interleukin-6 receptor complex reduces
infarct size via inhibiting myocardial apopto-
sis. Lab Invest 85:1210-1223
71. Malato Y et al (2011) Fate tracing of mature
hepatocytes in mouse liver homeostasis and
regeneration. J Clin Invest 121:4850-4860
72. Mitchell C, Willenbring H (2008) A repro-
ducible and well-tolerated method for 2/3
partial hepatectomy in mice. Nat Protoc
3:1167-1170
73. Jackson LN et al (2008) PI3K/Akt activation
is critical for early hepatic regeneration after
partial hepatectomy. Am J Physiol Gastrointest
Liver Physiol 294:G1401-G1410
74. Maione D et al (1998) Coexpression of IL-6
and soluble IL-6R causes nodular regenera-
tive hyperplasia and adenomas of the liver.
EMBO J 17:5588-5597
75. Schirmacher P et al (1998) Hepatocellular
hyperplasia, plasmacytoma formation, and
extramedullary hematopoiesis in interleukin
(IL)-6/soluble IL-6 receptor double-trans-
genic mice. Am J Pathol 153:639-648
76. Peters M et al (1998) In vivo and in vitro activi-
ties of the gp130-stimulating designer cytokine
Hyper-IL-6. J Immunol 161:3575-3581
77. Drucker C et al (2009) Interleukin-6 trans-
signaling regulates glycogen consumption
after D -galactosamine-induced liver damage. J
Interferon Cytokine Res 29:711-718
78. Riehle KJ et al (2008) Regulation of liver
regeneration and hepatocarcinogenesis by
suppressor of cytokine signaling 3. J Exp Med
205:91-103

Biochim Biophys Acta

1813:878-888
56. Heinrich PC et al (1990) Interleukin-6 and
the acute phase response. Biochem J
265:621-636
57. Bollrath J et al (2009) gp130-mediated Stat3
activation in enterocytes regulates cell survival
and cell-cycle progression during colitis-asso-
ciated tumorigenesis. Cancer Cell 15:91-102
58. Grivennikov S et al (2009) IL-6 and STAT3
signaling is required for survival of intestinal
epithelial cells and colitis associated cancer.
Cancer Cell 16:103-113
59. Ernst M, Jenkins BJ (2004) Acquiring signal-
ling specificity from the cytokine receptor
gp130. Trends Genet 20:23-32
60. Smith AG et al (1988) Inhibition of pluripo-
tential embryonic stem cell differentiation by
purified polypeptides. Nature 336:688-690
61. Matsuda T et al (1999) STAT3 activation is
sufficient to maintain an undifferentiated state
of mouse embryonic stem cells. EMBO J
18:4261-4269
62. Ying QL et al (2008) The ground state of
embryonic stem cell self-renewal. Nature
453:519-523
63. Cressman DE et al (1996) Liver failure and
defective hepatocyte regeneration in
interleukin-6-deficient mice. Science 274:
1379-1383
64. Hecht N et al (2001) Hyper-IL-6 gene ther-
apy reverses fulminant hepatic failure. Mol
Ther 3:683-687