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AS/Epo
AS
Epo
Control
Fig. 4
Univariate analysis of survival (spss 11.5) showing benefit of the drug
combination artesunate-erythropoietin (AS/Epo) on survival compared to artesu-
nate treatment alone (AS)
500-5,000 IU/kg, a small proportion of circulating rhuEpo
does cross the BBB (
9
). rhuEpo large molecular size (37 kDa),
high glycosylation and negative charge could explain the small
proportion of BBB passage (
10
).
2. It has been recently described that the hematopoietic and non-
hematopoietic functions of Epo are mediated through differ-
ent receptors (Fig.
2
). Whereas Epo receptor homodimers
mediate the hematopoietic response, the tissue protective
activities of Epo are mediated by a heterodimeric receptor
composed of Epo receptor associated with the common beta
receptor subunit, also known as CD131 (
11
). Binding of a
tissue-protective molecule initiates signaling via phosphoryla-
tion of JAK-2 activating multiple downstream pathways that
promote tissue protection (
11
).
3. There is at least one major difference between the mouse
model of cerebral malaria and human cerebral malaria that
needs to be considered. During human cerebral malaria, the
predominant cell type sequestered on the endothelium of the
cerebral microvasculature is PRBCs. Whereas mice develop
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