Biology Reference
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Table 1
Typical evolution of biological and clinical signs during the follow-up
of untreated CM mice
Day post-infection
Clinical stage
Parasitemia
Death
0-3
0
<0.01
0
4
0
1-3%
0
5
1
3-5%
0
6
2
5-8%
0
7
3
8-12%
20%
8-10
3-4
>12%
80%
Fig. 2 Clinical presentation, parasitemia, and death rate of CM-untreated mice
Day 6: most mice at the second stage of cerebral malaria.
Day 7: severe clinical signs or death for a minority of mice.
Days 8-10: severe clinical signs or death for a majority of
mice.
Day 10: more than 80% of mice are dead.
Clinical presentations of untreated mice, mice treated with
Epo, Artesunate, and Artesunate Epo according to BIENVENU
score ( 8 ) are presented below (Fig. 3 ):
Survival of mice treated with Epo, Artesunate, and Artesunate
Epo compared to Control is presented below (Fig. 4 ):
The analysis of variance (ANOVA, p < 0.001) and the chi(2)
square test ( p < 0.01) will be used to compare the effects of the
different therapeutic options.
 
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