Biology Reference
In-Depth Information
Table 2
(continued)
Time of treatment
End-points
First author
and references
EPO, type and
doses (IU/kg)
Duration of
occlusion (min)
Date
Species
Relative to Isch/Rep
End-points
Outcomes
Treguer (
47
)
2010
Rat
Darbepoetin 1,000
i.v.
Right before Rep
45
At 7 days:
MI size
↓
p
< 0.001
Transmural MI
↓
p
< 0.001 (no
benefit on LV
function by
EPO with
conventional
echo)
Shen (
48
)
2010
Rat
rhEPO 100-5,000
i.v.
30 min before Isch
30
At 2 and 4 h:
Ventricular
arrhythmias
↓
p
< 0.05
TNFa, IL6
↓
p
< 0.05
Stein (
49
)
2010
Nude rat
rhEPO
200 U ± hEPCs
intramyocardial
At Rep
30
At 4 weeks:
Only EPC + EPO
MI size
p
= NS
Regional LV wall
motion
↑
p
< 0.05
LVEF
p
= NS
Vessel density
↑
p
< 0.05
EPC apoptosis
↓
p
< 0.05
Yano (
50
)
2011
Stroke-
prone rats
(SHR-SP)
EPO 5,000 i.v.
15 min before Isch
20
At 2 h: MI size
↓
p
< 0.05 in WKY
p
= NS in SHR-SP
*Only 1.5 dose
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