Biology Reference
In-Depth Information
Hirata (
16
)
2006
Dog
EPO 1,000 single
dose
0 min (0 min group) or
+6 h (6 h group) or + 1
week (1 week group)
NA
At 6 h: MI size
↓
p
< 0.05
At 1 week: CD34+
cells
↑
p
< 0.05
At 4 weeks:
MI size
↓
in 0 min group
ns in 6 h group
and 1 week
group
LVEF
↑
in 0 min and 6 h
ns in 1 week
Capillary density
↑
in 0 min and 6 h
ns in 1 week
Chua (
17
)
2011
Mini-
pigs
EPO 7,500 repeated
doses
+30 min and +24 h
NA
At 14 days:
Apoptosis
↓
p
< 0.001
Fibrosis
↓
p
< 0.01
Capillary density
↓
p
< 0.05
MI size
↓
p
< 0.05
LVEF
↓
p
< 0.05
Ahmet (
12
)
2011
Rat
Epoetin alfa 3,000
single dose
0 min
NA
At 24 h:
Apoptosis
↓
(80%)
p
< 0.05
Inflammation
↓
(30%)
p
< 0.05
MI size
↓
(50%)
p
< 0.05
At 8weeks:
MI size
↓
p
< 0.05
LVEDV
↓
p
< 0.05
LVESV
↓
p
< 0.05
LVEF
↑
p
< 0.05
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