Biology Reference
In-Depth Information
Table 1
Animal experiments (permanent occlusion)
Time of EPO
End-points
First author
and references
EPO, type and doses
(IU/kg)
Relative to
reperfusion
Date
Species
Relative to occlusion
End-points
Outcomes
Tramontano (
7
) 2003
Rat
EPO, 3,000 single
dose
0 min
NA
At 60 min: apoptosis
in the AAR
↓
p
< 0.001
Moon (
8
)
2003
Rat
Epoetin alfa, 3,000
single dose
0 min
NA
At 24 h: apoptosis
in the AAR
↓
50%
p
< 0.001
8 weeks:
MI size
↓
80%
p
< 0.001
LVEDV
↓
p
< 0.002
LVESV
↓
p
< 0.005
LVEF
↑
p
< 0.001
Parsa (
13
)
2003
Rabbits
Epoetin alfa, 5,000
single dose
0 min
NA
At 6 h: apoptosis
↓
p
< 0.001
At 4 days:
AAR
ns
MI size
↓
p
< 0.1
Van der Meer
(
14
)
2005
Rat
Darbepoetin alfa,
8,000 single dose
or repeated
(1) 0 min or (2)
0 min + every 3 weeks
or (3) +3 weeks + every
3 weeks
NA
At 9 weeks: MI size
↓
(1)
p
< 0.01
↓
(2)
p
< 0.01
ns (3)
Capillary density
↑
(1, 2, 3)
p
< 0.01
(continued)
Search WWH ::
Custom Search