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9. Grimm C, Wenzel A, Groszer M et al (2002)
HIF-1-induced erythropoietin in the hypoxic
retina protects against light-induced retinal
degeneration. Nat Med 8:718-724
10. Junk AK, Mammis A, Savitz SI et al (2002)
Erythropoietin administration protects retinal
neurons from acute ischemia-reperfusion injury.
Proc Natl Acad Sci U S A 99:10659-10664
11. Grimm C, Wenzel A, Stanescu D et al (2004)
Constitutive overexpression of human eryth-
ropoietin protects the mouse retina against
induced but not inherited retinal degenera-
tion. J Neurosci 24:5651-5658
12. Rex TS, Wong Y, Kodali K, Merry S (2009)
Neuroprotection of photoreceptors by direct
delivery of erythropoietin to the retina of the
retinal degeneration slow mouse. Exp Eye Res
89:735-740
13. Yamasaki M, Mishima HK, Yamashita H et al
(2005) Neuroprotective effects of erythropoi-
etin on glutamate and nitric oxide toxicity in
primary cultured retinal ganglion cells. Brain
Res 1050:15-26
14. Tsai JC, Wu L, Worgul B et al (2005)
Intravitreal administration of erythropoietin
and preservation of retinal ganglion cells in an
experimental rat model of glaucoma. Curr Eye
Res 30:1025-1031
15. Zhong L, Bradley J, Schubert W et al
(2007) Erythropoietin promotes survival
of retinal ganglion cells in DBA/2J glau-
coma mice. Invest Ophthalmol Vis Sci
48:1212-1218
Weishaupt JH, Rohde G, Polking E et al
(2004) Effect of erythropoietin axotomy-
induced apoptosis in rat retinal ganglion cells.
Invest Ophthalmol Vis Sci 45:1514-1522
17. King CE, Rodger J, Bartlett C et al (2007)
Erythropoietin is both neuroprotective and
neuroregenerative following optic nerve
transection. Exp Neurol 205:48-55
18. Wang ZY, Shen LJ, Tu L et al (2009)
Erythropoietin protects retinal pigment epi-
thelial cells from oxidative damage. Free Radic
Biol Med 46:1032-1041
19. Chung H, Lee H, Lamoke F et al (2009)
Neuroprotective role of erythropoietin by
antiapoptosis in the retina. J Neurosci Res
87:2365-2374
20. Zhang J, Wu Y, Jin Y et al (2008) Intravitreal
injection of erythropoietin protects both reti-
nal vascular and neuronal cells in early diabe-
tes. Invest Ophthalmol Vis Sci 49:732-742
21. Auricchio A, Rivera VM, Clackson T et al
(2002) Pharmacological regulation of protein
expression from adeno-associated viral vectors
in the eye. Mol Ther 6:238-242
22. Lebherz C, Auricchio A, Maguire AM et al
(2005) Long-term inducible gene expression
in the eye via adeno-associated virus gene
transfer in nonhuman primates. Hum Gene
Ther 16:178-186
23. Surace EM, Auricchio A (2008) Versatility of
AAV vectors for retinal gene transfer. Vision
Res 48:353-359
24. Allocca M, Tessitore A, Cotugno G, Auricchio
A (2006) AAV-mediated gene transfer for reti-
nal diseases. Expert Opin Biol Ther
6:1279-1294
25. Simonelli F, Ziviello C, Testa F et al (2007)
Clinical and molecular genetics of Leber's con-
genital amaurosis: a multicenter study of Italian
patients.
Invest
Ophthalmol
Vis
Sci
48:4284-4290
26. Bainbridge JW, Smith AJ, Barker SS et al
(2008) Effect of gene therapy on visual func-
tion in Leber's congenital amaurosis. N Engl J
Med 358:2231-2239
27. Maguire AM, Simonelli F, Pierce EA et al
(2008) Safety and efficacy of gene transfer for
Leber's congenital amaurosis. N Engl J Med
358:2240-2248
28. Cideciyan AV, Aleman TS, Boye SL et al
(2008) Human gene therapy for RPE65
isomerase deficiency activates the retinoid cycle
of vision but with slow rod kinetics. Proc Natl
Acad Sci U S A 105:15112-15117
29. Hauswirth WW, Aleman TS, Kaushal S et al
(2008) Treatment of Leber congenital amau-
rosis due to RPE65 mutations by ocular sub-
retinal injection of adeno-associated virus gene
vector: short-term results of a phase I trial.
Hum Gene Ther 19:979-990
30. Cideciyan AV, Hauswirth WW, Aleman TS
et al (2009) Vision 1 year after gene therapy
for Leber's congenital amaurosis. N Engl J
Med 361:725-727
31. Cideciyan AV, Hauswirth WW, Aleman TS,
Kaushal S et al (2009) Human RPE65 gene
therapy for Leber congenital amaurosis: persis-
tence of early visual improvements and safety
at 1 year. Hum Gene Ther 20:999-1004
32. Simonelli F, Maguire AM, Testa F et al (2009)
Gene therapy for Leber's congenital amaurosis
is safe and effective through 1.5 years after vec-
tor administration. Mol Ther 18(3):643-650
33. Stein L, Roy K, Lei L, Kaushal S (2011)
Clinical gene therapy for the treatment of
RPE65-associated Leber congenital amaurosis.
Expert Opin Biol Ther 11:429-439
34. Rex TS, Allocca M, Domenici L et al (2004)
Systemic but not intraocular Epo gene transfer
protects the retina from light- and
genetic-induced degeneration. Mol Ther 10:
855-861
35. Brines M, Cerami A (2005) Emerging biologi-
cal roles for erythropoietin in the nervous sys-
tem. Nat Rev Neurosci 6:484-494
36. Rosenzweig MQ, Bender CM, Lucke JP et al
(2004) The decision to prematurely terminate
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