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Fig. 2
The effects of ARA290 on the development of (
a
) mechanical allodynia and
(
b
) heat hyperalgesia in the neuritis model. Part (
a
) is the mean von Frey thresh-
olds on the ipsilateral side. In the vehicle group (
n
= 9), mechanical allodynia
peaked on day 4 post neuritis but showed signs of reversal by day 7. Following the
i.p. injection of 120
g/kg ARA290 (
n
= 9) there was a clear reduction in the devel-
opment of mechanical allodynia. Part (
b
) is the mean paw withdrawal latencies in
response to the radiant heat source on the ipsilateral side. In the vehicle group
(
n
= 9), heat hyperalgesia peaked on day 3 post neuritis but showed signs of rever-
sal by day 7. Following injection of 120
μ
g/kg ARA290 (
n
= 9) there was a reduc-
tion in the development of heat hyperalgesia on day 3. Error bars = SEM, *
p
< 0.05
compared to the vehicle group at individual time points (unpaired
t
test) ( Data
modi fi ed from
33
)
μ
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