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Fig. 2 The effects of ARA290 on the development of ( a ) mechanical allodynia and
( b ) heat hyperalgesia in the neuritis model. Part ( a ) is the mean von Frey thresh-
olds on the ipsilateral side. In the vehicle group ( n = 9), mechanical allodynia
peaked on day 4 post neuritis but showed signs of reversal by day 7. Following the
i.p. injection of 120
g/kg ARA290 ( n = 9) there was a clear reduction in the devel-
opment of mechanical allodynia. Part ( b ) is the mean paw withdrawal latencies in
response to the radiant heat source on the ipsilateral side. In the vehicle group
( n = 9), heat hyperalgesia peaked on day 3 post neuritis but showed signs of rever-
sal by day 7. Following injection of 120
μ
g/kg ARA290 ( n = 9) there was a reduc-
tion in the development of heat hyperalgesia on day 3. Error bars = SEM, * p < 0.05
compared to the vehicle group at individual time points (unpaired t test) ( Data
modi fi ed from 33 )
μ
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