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Fig. 2 EPO prevent changes in thermal and mechanical thresholds in diabetic
rats. Control or STZ-diabetic rats were treated according to the preventive sched-
ule (study 1). ( a ) Thermal sensitivity threshold is expressed as thermal response
latency in seconds. ( b ) Mechanical threshold is expressed as force withdrawal
latency in grams. CTRL: untreated control rats; CTRL+EPO: Healthy rats treated
with EPO; STZ: untreated diabetic rats; STZ+EPO: diabetic rats treated with EPO.
Data are mean ± SEM. * P < 0.05 vs. STZ
Five weeks after STZ injection the reduction in NCV in the
diabetic group (−21%) of CTRL group was partially but significantly
counteracted (by 14%) by EPO in rats treated according to the
protection schedule (Fig. 4 ). Immediately before the beginning of
treatment, at randomization, NCV was significantly reduced
( P < 0.001) in STZ compared to control groups. EPO according to
the therapeutic schedule counteracted this decrease in the diabetic
groups (from −42% of the diabetic rats to −23% of EPO-treated
rats), while it did not have any effect in control rats (Fig. 4 ).
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