Biology Reference
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Fig. 1 Preventive and therapeutic EPO treatment improves the clinical course of EAE. Mice were immunized
with MOG and treated with vehicle or EPO (50
g/kg), i.p., 3 days a week, starting at day 3 after immunization
(preventive schedule) or at disease onset (therapeutic schedule). The clinical score ( panel A ) and the body
weight ( panel B ) are reported. Data are the mean ± S.E.M. Vehicle, n = 9; EPO preventive, n = 9; EPO therapeu-
tic, n = 8; healthy mice n = 5. * P < 0.05, ** P < 0.01 by Mann-Whitney test (reproduced with permission from
Savino et al. J Neuroimmunol. 2006;172:27-37)
μ
4
Notes
1. The emulsion is ready when a small drop placed on the surface
of cold distilled water does not disperse instantly but main-
tains its integrity.
2. It is better to fill a syringe completely to avoid waste of the
emulsion.
3. If the subcutaneous injection is well done it should be possible
to see a lump in the injection area. The emulsion is injected
subcutaneously in three different sites to allow a better
adsorption.
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