Biology Reference
In-Depth Information
Fig. 1
Preventive and therapeutic EPO treatment improves the clinical course of EAE. Mice were immunized
with MOG and treated with vehicle or EPO (50
g/kg), i.p., 3 days a week, starting at day 3 after immunization
(preventive schedule) or at disease onset (therapeutic schedule). The clinical score (
panel A
) and the body
weight (
panel B
) are reported. Data are the mean ± S.E.M. Vehicle,
n
= 9; EPO preventive,
n
= 9; EPO therapeu-
tic,
n
= 8; healthy mice
n
= 5. *
P
< 0.05, **
P
< 0.01 by Mann-Whitney test (reproduced with permission from
Savino et al. J Neuroimmunol. 2006;172:27-37)
μ
4
Notes
1. The emulsion is ready when a small drop placed on the surface
of cold distilled water does not disperse instantly but main-
tains its integrity.
2. It is better to fill a syringe completely to avoid waste of the
emulsion.
3. If the subcutaneous injection is well done it should be possible
to see a lump in the injection area. The emulsion is injected
subcutaneously in three different sites to allow a better
adsorption.
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