Biomedical Engineering Reference
In-Depth Information
CHAPTER 2
Functional Multilayered
Polyelectrolyte Assemblies on
Biological Cells
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BEN WANG
a,b
a
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention,
Ministry of Education), The Second Aliated Hospital, Zhejiang University
School of Medicine, Hangzhou, Zhejiang 310009, China;
b
Institute for
Translational Medicine, School of Medicine, Zhejiang University,
Hangzhou, Zhejiang 310029, China
Email: benwang@zju.edu.cn
.
2.1 Layer-by-Layer (LbL) Polyelectrolyte Assembly
2.1.1 Self-Assembly and Emerging of LbL Polyelectrolyte
Assembly
Nature exploits self-organization of multiple materials to produce biopoly-
mer fibers, cell membranes, the flagellar motor, viruses, hard tissue and
other multiple-scale organic-inorganic hybrid structures in many ways. Self-
assembly is one of the forces behind the bottom-up construction of well-
ordered structures at the nanometer scale. It typically occurs through
reversible interactions that slowly arrange building blocks into the most
thermodynamically favored structure, which is the fundamental process,
and generates structural organization across scales.
1
This process relies on
molecular recognition between building blocks through noncovalent inter-
actions, such as van der Waals and electrostatic forces, hydrogen bonding
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