Prominent Ligand Types in Modern Cross-Coupling Reactions - New Trends in Cross-Coupling: Theory and Applications - page 43

Pd(OAc) 2 / CyPF t Bu
NaO t -Bu

( t -Bu) 2 P

n -OctylNH 2 N(H) n -Octyl

Cl

Me

90 - 100 °C

N N

N(H) n -Octyl

PCy 2

N(H) n -Octyl

Fe

N N(H) n -Octyl

N

N

CyPF t Bu

0.001 % Pd
86 %

0.005% Pd
93 %

0.01 % Pd
83 %

Figure 2.25 Aryl aminations of chloropyridines using Josiphos CyPFtBu.