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Pd(dba)
2
/ P(
t
-Bu)
3
LiNCy
2
Br
MeO
O
O
Me
O
t
-Bu
toluene, rt, 24 h
MeO
O
t
-Bu
95 %
{[P(
t
-Bu)
3
]PdBr}
2
LiNCy
2
Br
Me
2
N
O
O
Me
OMe
toluene, rt, 4 h
Me
2
N
OMe
Me
Me
Me
88 %
{[P(
t
-Bu)
3
]PdBr}
2
NaHMDS
Cl
MeO
O
O
Me
O
t
-Bu
toluene, rt, 4 h
MeO
O
t
-Bu
Me
88 %
Figure 2.13 Ester enolate arylation using P(t-Bu)
3
complexes.
n
-Bu
P
B(OH)
2
Pd(OAc)
2
(0.005 mol %)
Ad
2
P(
n
-Bu) (0.01 mol%)
K
3
PO
4
Toluene, 100 °C
Cl
R
R
55 - 100 %
Ad
2
P(
n
-Bu)
Figure 2.14
Suzuki-Miyaura reactions using Ad
2
P(n-Bu).
Ad
2
PR Ligands Reported by Beller:
Me
n
-Bu
Bn
Allyl
Me
P
P
P
P
P
Me
Synthesis of Ad
2
PR Ligands:
H
R
R
X
PH
P
P
Et
3
N
RX
63 - 93 %
Figure 2.15 Ad
2
PR ligand family (top) and synthesis (bottom).
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