Chemistry Reference
In-Depth Information
CHAPTER 15
Recent Large-Scale
Applications of Transition
Metal-Catalyzed Couplings
for the Synthesis of
Pharmaceuticals
JAVIER MAGANO*
a
AND JOSHUA R. DUNETZ
b
a
Chemical Research and Development, Pfizer Global Research and
Development, Eastern Point Road, Groton, CT 06340, USA;
b
Process
Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA
*Email: javier.magano@pfizer.com
15.1 Introduction
Transition metal-catalyzed couplings
1
are well-established technologies that
have found widespread application in both academic and industrial settings.
Intense research in this area for the past four decades has resulted in an
outstanding variety of catalytic systems that allow for the formation of C-C
and C-heteroatom bonds under very mild conditions and that are
applicable to a very broad range of substrates. Since the 1990s, the number
of patents and publications in this area has grown exponentially and
couplings such as Suzuki-Miyaura, Heck, Sonogashira and Negishi have
been reported by the thousands.
2
Palladium is overwhelmingly the most
Search WWH ::
Custom Search