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H
2
Cl
Cl
NO
2
QP-TU
Pt/C
+
NH
2
Cl
30 °C
Metal
Scavenging
Hydrogenation
160 °C
77%
SMC
Reaction
Batch
B(OH)
2
Cl
N
N
O
Cl
Boscalid
Figure 13.9 Continuous flow synthesis of a key intermediate in the synthesis of
boscalid: multistep synthesis enabled by an intermediate purification
by means of immobilized scavengers and catalysts.
B(OH)
2
XPhos precat (2 mol%),
aq. TBAB, aq. K
3
PO
4
2M HCl
OH
organic
R
+
R
Tf
2
O
90 °C
aqueous
SMC Reaction
RT
Triflate
For
m
at
i
on
Micr oext racti on
F
S
N
CF
3
O
F
O
MeO
MeO
Me
Me
F
O
n
-Hex
Me
99%
99%
83%
93%
96%
Figure 13.10 Continuous flow synthesis of biaryls via a triflate-SMC reaction se-
quence: multistep synthesis enabled by a microextraction.
triflates. Excess of triflic anhydride and ammonium salt by-products were
removed via a microfluidic extraction. The organic phase was subsequently
merged with XPhos precat (2 mol%), boronic acids, tetrabutylammonium
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