Chemistry Reference
In-Depth Information
Entry Solid support
Cross-coupling reaction
Advantages
Leaching degree Ref.
1
Carbon
Cheap
High (89% Pd
was leached
after 12
reactions)
11
I
Pd/C
CO
2
Bu
+
CO
2
Bu
Et
3
N, MeCN, 170 ºC
NC
NC
81%
(+ 10% homocoupling + 9% reduction)
2
Silicon dioxide
Good chemical
stability
Good thermal
stability
Cheap and
abundant No
swelling
Low (10 ppb in
organic phase,
20 ppb in
aqueous
phase)
12
OMe
Me
Me
Siliacat DPP-Pd
(HO)
2
B
Br
+
KOH, THF/H
2
O, 60 ºC
5minresidencetime
OMe
>95%
1.71mmol/hduring8h
TON > 100
3
Polymer
supports
Wide variety of
different
supports
Allows fine
tuning of the
support
(metal-
support
interaction,
pressure
drop, etc.)
Low (10 ppm)
13
Me
I
B(OH)
2
PdEnCat
+
Bu
4
NOMe, scCO
2
/MeOH(10:1),
100ºC,166bar
Me
81%
4
Magnetic
nanoparticles
Allows for
simultaneous
heating via
magnetic
induction
Low (100 ppm
for Heck; 34
ppm for
Suzuki-
Miyaura)
14
I
Pd on magnetic NP
S
S
+
Bu
3
N, DMF,
120 ºC
63%
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