Direct Arylation via C–H Activation - New Trends in Cross-Coupling: Theory and Applications - page 551

CHAPTER 12
Direct Arylation via C-H
Activation
UPENDRA SHARMA, ATANU MODAK, SOHAM MAITY,
ARUN MAJI AND DEBABRATA MAITI*
Department of Chemistry, IIT Bombay, Powai, Mumbai-400076, India
*Email: [e-mail]
12.1 Introduction
The discovery of new strategies and protocols that can improve a transfor-
mation in terms of number of steps, atom economy and versatility in
the construction of complex scaffolds is a continuing target for chemists.
In this context, the expanding frontier of C-H bond activation is one of the
most attractive research areas of recent decades. The development of
catalytic functionalization of unactivated C-H bonds for the synthesis of
carbon-carbon and carbon-heteroatom bonds has revolutionized the whole
approach towards the synthesis of practically important compounds. 1-4
Progress in the direct regioselective conversion of C-H bonds to C-C
bonds has challenged the classical catalytic cross-coupling reactions in-
volving organohalides along with organometallic coupling partners. 5 Despite
significant progress in this area, the challenges still persist in terms of se-
lectivity of C-H bond activation, realization of truly ecient catalytic systems
and generality of reaction conditions. In this regard, several metal catalysts
have been examined based on conscious judgments over time as under-
standing has gradually increases. Broadly, these transformations involve
(a) activation of a C-H bond selectively followed by metallation, (b) addition
of a coupling partner to the metal center and (c) reductive elimination of the