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O
OTBS
MeO
Me
N
O
OTBS
HO
Me
Me
H
Me
MeO
Me
N
7.20
Br
Pd(PPh
3
)
4
Tl
2
CO
3
84%
Me
Me
Me
OH
Br
H
H
O
+
H
Br
B(OH)
2
H
O
OTBS
OTBS
Me
H
O
TBDPSO
TBDPSO
OTBS
OTBS
Me
(
−
)-FR182877
Me
Me
7.21
7.22
Scheme 7.9 Total synthesis of (-)-FR182877 featuring selective cross-couplings of gem-dibromoolefin 7.20.
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