Chemistry Reference
In-Depth Information
CHAPTER 7
Pd(0)-Catalyzed
Carboiodination: Early
Developments and Recent
Advances
DAVID A. PETRONE,
y
a
CHRISTINE M. LE,
y
a
STEPHEN G. NEWMAN
b
AND MARK LAUTENS*
a
a
Department of Chemistry, University of Toronto, 80 St George Street,
Toronto, Ontario, Canada M5S 3H6;
b
Centre for Catalysis Research and
Innovation, Department of Chemistry, University of Ottawa, 10 Marie
Curie, Ottawa, Ontario, Canada K1N 6N5
*Email: mlautens@chem.utoronto.ca
7.1 Introduction
Palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Mizoroki-Heck,
Negishi, Buchwald-Hartwig reactions) have become the premier approach to
forge carbon-carbon and carbon-heteroatom bonds. Over the past several
decades, major developments in this field have been achieved that have
allowed many exceptionally challenging cross-couplings to be realized,
facilitating the step-ecient synthesis of complex pharmaceuticals and
biologically active natural products. Despite these enormous advances,
opportunities exist to find new reactivity that can further diversify the range
y
These authors contributed equally to the writing of this chapter.
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