Ancillary Ligand Design in the Development of Palladium Catalysts for Challenging Selective Monoarylation Reactions - New Trends in Cross-Coupling: Theory and Applications - page 251

permitting such advances, with sterically demanding mono- and bidentate
phosphine-based ligands proving most effective; from a practical perspective,
many of the ancillary ligands featured in this discussion are both air stable
and commercially available. Although some ligand structural motifs appear
to be particularly effective in promoting various palladium-catalyzed mono-
arylation reactions of this type, no single ligand class has emerged as being
uniquely privileged. The benefits of using well-defined and rationally pre-
pared precatalysts in which palladium is coordinated to the ancillary ligand
of choice is also rearmed in the examples documented here; doing so has
provided access to unprecedented monoarylation reaction scope under mild
conditions. It is evident that further advances in ancillary ligand design and
the use of rationally assembled precatalysts will figure prominently in ad-
dressing outstanding challenges in monoarylation chemistry.

Acknowledgements
The author acknowledges support from the Natural Sciences and Engin-
eering Research Council of Canada, the Killam Trusts and Dalhousie Uni-
versity (Alexander McLeod Professorship).

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