Advances in C–C and C–X Coupling Using Palladium–NHeterocyclic Carbene (Pd–NHC) Complexes - New Trends in Cross-Coupling: Theory and Applications - page 187

COCl

OBn OH

Pd(OAc) 2 (10mol%)
IPr.HCl(10mol%)

AcO OMe

AcO MeO

OMe OMe

+

N-ethylmorpholine
xylene, reflux

OMe

61 (IC 50 =0.1 μ M)

43%

OMe OH

OBn

Scheme 4.37 Preparation of the potent growth inhibitor 61 using a Heck reaction catalysed by a Pd-NHC complex as the key step.